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For example, activation of transient receptor potential ankyrin 1 (TRPA1) induces Ca influx, promoting calmodulin-dependent protein kinase II (CaMKII) phosphorylation, and Nrf2 nuclear translocation, which upregulates GPX4 to inhibit ferroptosis in high-glucose-exposed endothelial cells, thereby improving cell migration, proliferation, and tube formation to enhance diabetic wound healing [87]

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Swedish Geological Company-SGAB/ Corporacion nicaragense de Minas-INMINE/Swedish Agency for Research Cooperation with Developing Countries-SAREC report, URAP 89001, pp 26 DeMets C (2001) A new estimate for present-day Cocos-Caribbean Plate motion: implications for slip along the Central American Volcanic Arc

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Nevertheless, this does not unambiguously prove that induction of conformational change is required for neutralization by this antibody